Less perturbing fluorescent labels
tCOTP is a proprietary fluorescent label that allows researchers to track and quantify mRNA while preserving its natural behavior.
Unlike traditional fluorescent dyes, using nucleotide bases as labels offer:
- Minimal impact on RNA structure and function, allowing normal ribosomal translation.
- Accurate real-time tracking in fluorescence microscopy and flow cytometry.
- Scalability for high-throughput applications, facilitating robust experimental workflows.
What are base analogues?
Base analogues like tCOTP replace the normal building blocks in the mRNA’s code. Because they’re small and integrate directly into the mRNA sequence, they let you see exactly what’s going on in your cells without messing up the results
Shedding light without weighing down your mRNA.
Unlike traditional dyes, which stick to the outside and weigh everything down, base analogues are part of the genetic message itself. This Stealthy approach means you get clear data and reliable answers faster.
Traditional labeling technologies
LanteRNA’s solution
How it works.
Our tCO Stealth Labels are nucleoside analogs of cytosine, which are partially replaced in mRNA during synthesis depending on your desired incorporation degree. They are currently available through our partners at Jena Bioscience. Learn more here
Scientific validation
& case studies.
Our technology has been validated in high-impact publications and through collaborations with leading academic and pharmaceutical institutions.
✓ 40–50% retention of translational activity compared to unlabeled mRNA.
✓Successful integration into existing mRNA synthesis workflows.